Effect of Physicochemical Properties of Ophthalmic Formulations on Ocular Bioavailability Program
Page 2

Furthermore, it is also noted that suitable bioequivalence methods are lacking for many generic ophthalmic formulations, including suspensions and emulsions. Therefore an investigation of the relationship between various physicochemical properties and their effect on ocular bioavailability will help the FDA in establishing guidelines for the determination of bioequivalence of ophthalmic suspensions and emulsions.

The scope of the program will cover two types of inquiries:

a) In vitro study – Formulations with different physicochemical properties are manufactured using a selected steroid and characterized in vitro. Drug release and stability tests are conducted to understand how differences in physicochemical properties may affect ocular bioavailability.

b) In vivo study – Formulations selected based on the results of the in vitro study are tested in an animal model. A pharmacokinetic study should be conducted by assessing the ocular distribution of the steroid in various eye tissues and organs at various time points.

In order to support these initiatives, the Food and Drug Administration is set to administer funds in the amount of $400,000.

The institutions and organizations who will be deemed eligible to submit an application under this program are the following:

a) Private and Public Non-profit entities

b) State and Local Governments

c) Indian Tribal Governments and Organizations

d) Faith-based Organizations

e) Community-based Organizations

f) Institutions of Higher Education

g) Private and Public Colleges and Universities

h) Independent School Districts

The United States Department of Health and Human Services, the mother agency funding the Effect of Physicochemical Properties of Ophthalmic Formulations on Ocular Bioavailability Program, is country's premiere agency for protecting the health of all Americans and providing essential human services, especially to those who medically challenged and vulnerable.

Effect of Physicochemical Properties of Ophthalmic Formulations on Ocular Bioavailability Program
  Back to Page 1

About The Author Iola Bonggay is an editor of TopGovernmentGrants.com one the the most comprehensive Websites offering information on government grants and federal government programs. She also maintains Websites providing resources on environmental grants and grants for youth programs.

Additional Resources

category - Health Grants

Academic-Community Partnership Conference Series Program
In line with this mission, the National Institutes of Health has recently formed a partnership with the The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to establish the Academic-Community Partnership Conference Series Program wherein both agencies seek to solicit grant application that intend to conduct health disparities-related meetings, workshops, symposiums.

---

Eradication of HIV from CNS Reservoirs: Implications for Therapeutics Grant Program
The National Institutes of Health has collaborated with The National Institute of Mental Health (NIMH), The National Institute of Neurological Disorders and Stroke (NINDS), and The National Institute of Allergy and Infectious Disease (NIAID) in an attempt to establish the Eradication of HIV from CNS Reservoirs: Implications for Therapeutics Grant Program.

---

Critical Congenital Heart Disease Newborn Screening Demonstration Program
The Health Resources and Services Administration has recently constituted the Critical Congenital Heart Disease (CCHD) Newborn Screening Demonstration Program in order to support and encourage the development, dissemination, and validation of screening protocols and newborn screening infrastructure for point of care screenings that are specific to Critical Congenital Heart Diseases.

---

Environmental Exposures and Health: Exploration of Non-Traditional Settings Program
In according with this mission, the National Institutes of Health has partnered with the National Institute of Nursing Research (NINR) and the National Institute of Environmental Health Sciences (NIEHS) to establish the Environmental Exposures and Health: Exploration of Non-Traditional Settings Program.

---