Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.

by: Iola Bonggay

The United States Food and Drug Administration, otherwise referred to as the USFDA, an agency operating within the United States Department of Health and Human Services that is generally responsible for protecting and promoting public health through the regulation and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs, vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices, veterinary products, and cosmetics.

The USFA has recently formed a collaboration with the National Institutes of Health to establish the Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.

The primary goal of the program is to develop computational fluid dynamics (CFD) model of orally inhaled drug products that can account for drug product characteristics and physiological parameters on total and regional deposition in the lungs.

This is all in conjunction with the USFDA's objective of developing a CFD model that will be capable of of predicting highly localized deposition of pharmaceutically relevant polydisperse aerosols from metered dose inhalers (MDIs) and dry powder inhalers (DPIs).

In addition, the results that will be derived from this study will then be utilized to create a linked CFD-compartment model that can predict the effects of lung deposition on safety (systemic exposure) and efficacy (local delivery) for locally acting orally inhaled drugs.

  (continued...)

Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.
  Page 2

About The Author Iola Bonggay is an editor of TopGovernmentGrants.com one the the most comprehensive Websites offering information on government grants and federal government programs. She also maintains Websites providing resources on environmental grants and grants for youth programs.

Additional Resources

category - Health Grants

Cancer Prevention, Control, Behavioral Sciences, and Population Sciences Career Development Award Program
The National Institutes of Health has recently form a partnership with the National Cancer Institute in an effort to establish the Cancer Prevention, Control, Behavioral Sciences, and Population Sciences Career Development Award Program.

---

Biodemography of Aging Program
The National Institutes of Health has formed a partnership with the National Institute on Aging (NIA) in an effort to establish the Biodemography of Aging Program wherein they intend to solicit applications with the intent to conduct research studies regarding demographic and life-science approaches that could potentially expand the current understanding of aging, frailty and mortality.

---

Effect of Physicochemical Properties of Ophthalmic Formulations on Ocular Bioavailability Program
In this capacity, the Food and Drug Administration has recently established the Effect of Physicochemical Properties of Ophthalmic Formulations on Ocular Bioavailability Program in an attempt to study the effects of various physicochemical properties of ophthalmic suspensions and emulsions on ocular bioavailability.

---

Improving Health of People with Intellectual Disabilities Program
In keeping with this mission, the Centers for Disease Control and Prevention has constituted the Improving Health of People with Intellectual Disabilities Program in an attempt to financially support initiatives for people suffering from intellectual disabilities, thereby seeking to increase healthy behaviors and improve access to appropriate health services.

---