Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.

by: Iola Bonggay

The United States Food and Drug Administration, otherwise referred to as the USFDA, an agency operating within the United States Department of Health and Human Services that is generally responsible for protecting and promoting public health through the regulation and supervision of food safety, tobacco products, dietary supplements, prescription and over-the-counter pharmaceutical drugs, vaccines, biopharmaceuticals, blood transfusions, medical devices, electromagnetic radiation emitting devices, veterinary products, and cosmetics.

The USFA has recently formed a collaboration with the National Institutes of Health to establish the Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.

The primary goal of the program is to develop computational fluid dynamics (CFD) model of orally inhaled drug products that can account for drug product characteristics and physiological parameters on total and regional deposition in the lungs.

This is all in conjunction with the USFDA's objective of developing a CFD model that will be capable of of predicting highly localized deposition of pharmaceutically relevant polydisperse aerosols from metered dose inhalers (MDIs) and dry powder inhalers (DPIs).

In addition, the results that will be derived from this study will then be utilized to create a linked CFD-compartment model that can predict the effects of lung deposition on safety (systemic exposure) and efficacy (local delivery) for locally acting orally inhaled drugs.

  (continued...)

Predictive Lung Deposition Models for Safety and Efficacy of Orally Inhaled Drug Products Program.
  Page 2

About The Author Iola Bonggay is an editor of TopGovernmentGrants.com one the the most comprehensive Websites offering information on government grants and federal government programs. She also maintains Websites providing resources on environmental grants and grants for youth programs.

Additional Resources

category - Health Grants

Money Follows the Person Rebalancing Grant Demonstration Program
The Centers for Medicare & Medicaid Services has recently established the Money Follows the Person Rebalancing Grant Demonstration Program wherein they aim to assist the states to balance their long-term care systems and help Medicaid enrollees transition from institutions to communities.

---

Harnessing Advanced Health Technologies to Drive Mental Health Improvement Program
The National Institutes of Health has collaborated with National Institute of Mental Health (NIMH) in order to constitute the establishment of the Harnessing Advanced Health Technologies to Drive Mental Health Improvement Program.

---

Competitive Revision for Technology Development Within Biomedical Technology Research Centers Program
The National Institutes of Health has formed a partnership with the National Center for Research Resources (NCRR) in an attempt to establish the Competitive Revision for Technology Development Within Biomedical Technology Research Centers Program.

---

Biomedical and Behavioral Research Innovations to Ensure Equity in Maternal and Child Health
the National Institutes of Health has recently partnered with the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) to establish the Biomedical and Behavioral Research Innovations to Ensure Equity (BRITE) in Maternal and Child Health Grant Program.

---